Human albumin serum (HAS) is secreted by the yeast at high level of expression. In this process, HSA requires more stability during fermentation and downstream processes.
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Recombinant Drosophila melanogaster acetylcholinesterase is produced extracellularly by Pichia Pastoris. Dana Company has made several mutations through genetic engineering on the mentioned sequence in order to improve its properties. The amount of expression and production is high, and it can be provided in industrial scale.
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Saccharomyces cerevisiae is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. These days, also, it can be applied in other industries like, food and feed, pharmaceutical etc.
Dana Company, with several years of research on various yeasts, is ready to set up a yeast production line.
Dana Co. has the technology to break yeast cell wall and then to produce various yeast based products. These yeast-derived products can be used as Yeast extract-savory, Human health, Animal nutrition, Plant nutrition.
Penicillin G amidase (PGA) (EC 22.214.171.124) is an enzyme applied in the antibiotic production industry. This enzyme has both amidase and acylase activities. PGA catalyzes the reaction of penicillin g to the 6-aminopenicillanate (6-APA).
This reaction is done due to PGA amidase activity. Subsequently, 6-APA is converted to amoxicillin or ampicillin by PGA acylation activity.
PGA can also make a mediator molecule called 7-ADCA from the precursor of Cephosporin G (Ceph G), which is converted to cephalexin by the same enzyme under different conditions:
Todays, antibiotic manufacturers use this enzyme extensively. This enzyme must be fixed on a polymer substrate so that it can be used in reaction tanks for several hundred cycles to produce the product.
Dana has the technology to produce and stabilize this enzyme. For further information, please contact us.